Fgf21^tm1Fdl
Targeted Allele Detail

Summary

• Symbol: Fgf21^tm1Fdl
• Name: fibroblast growth factor 21; targeted mutation 1, Francesco De Luca
• MGI ID: MGI:5427438
• Gene: Fgf21 Location: Chr7:45263314-45264914 bp, - strand Genetic Position: Chr7, 29.38 cM, cytoband B2
• Alliance: Fgf21^tm1Fdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184999
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced part of exon 1, all of exon 2 and the 5' region of exon 3. Mice lack detectable serum levels of the protein. (J:184999)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf21 Mutation: 22 strains or lines available

References

• Original: J:184999 Kubicky RA, et al., Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice. Endocrinology. 2012 May;153(5):2287-95
• All: 2 reference(s)