Apoe^{tm3(APOE_i4)Yhg}
Targeted Allele Detail

Summary

• Symbol: Apoe^{tm3(APOE_i4)Yhg}
• Name: apolipoprotein E; targeted mutation 3, Yadong Huang
• MGI ID: MGI:5427463
• Synonyms: ApoE4-fKI, E4⁺
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^{tm3(APOE_i4)Yhg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184138
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Apoe^{tm3(APOE_i4)Yhg} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOE (348)

  Apoe	(MGI:88057)

  The APOE 4 isoform is expressed

• Mutation details: The coding sequence (exons 2 through 4) was replaced with the corresponding human genomic sequence encoding isoform 4. A loxP site was inserted 5' of the human sequence and a neo cassette with a 5' loxP site was inserted downstream of the human sequence. (J:184138)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 158 strains or lines available

References

• Original: J:184138 Bien-Ly N, et al., Reducing human apolipoprotein E levels attenuates age-dependent Abeta accumulation in mutant human amyloid precursor protein transgenic mice. J Neurosci. 2012 Apr 4;32(14):4803-11
• All: 7 reference(s)