Tg(Mpz-RAF1/ESR1)A668Ayld
Transgene Detail

Summary

• Symbol: Tg(Mpz-RAF1/ESR1)A668Ayld
• Name: transgene insertion A668, Alison Lloyd
• MGI ID: MGI:5427464
• Synonyms: RafTR, Tg(P0-Raf1/ER)A668Alyd
• Transgene: Tg(Mpz-RAF1/ESR1)A668Ayld Location: unknown
• Alliance: Tg(Mpz-RAF1/ESR1)A668Ayld page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Mpz-RAF1/ESR1)A668Ayld expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RAF1 (5894)

  Raf1	(MGI:97847)

• Mutation details: A v-raf-leukemia viral oncogene 1 (Raf Kinase, Raf1)/ER (a tamoxifen-inducible human estrogen receptor ligand-binding domain) fusion gene was placed under the control of the rat myelin protein zero (Mpz) promoter. Line 668 was generated. (J:182703)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:182703 Napoli I, et al., A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo. Neuron. 2012 Feb 23;73(4):729-42
• All: 1 reference(s)