Nrbp1^tm1.1Dja
Targeted Allele Detail

Summary

• Symbol: Nrbp1^tm1.1Dja
• Name: nuclear receptor binding protein 1; targeted mutation 1.1, David J Adams
• MGI ID: MGI:5427569
• Synonyms: Nrbp1^flox
• Gene: Nrbp1 Location: Chr5:31398227-31408910 bp, + strand Genetic Position: Chr5, 17.27 cM
• Alliance: Nrbp1^tm1.1Dja page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184685
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 11. Flp-mediated recombination removed the neo cassette and left exons 5 through 11 floxed. (J:184685)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrbp1 Mutation: 52 strains or lines available

Notes

ES cell line = E14J (129P2/OlaHsd)

References

• Original: J:184685 Wilson CH, et al., Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. EMBO J. 2012;31(11):2486-97
• All: 1 reference(s)