Nrbp1^tm1.2Dja
Targeted Allele Detail

Summary

• Symbol: Nrbp1^tm1.2Dja
• Name: nuclear receptor binding protein 1; targeted mutation 1.2, David J Adams
• MGI ID: MGI:5427570
• Gene: Nrbp1 Location: Chr5:31398227-31408910 bp, + strand Genetic Position: Chr5, 17.27 cM
• Alliance: Nrbp1^tm1.2Dja page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184685
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed the neo cassette and exons 5 through 11. This deletion is hypothesized to disrupt the kinase-like domain and produce a null allele. (J:184685)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrbp1 Mutation: 52 strains or lines available

Notes

ES cell = E14J (129P2/OlaHsd)

References

• Original: J:184685 Wilson CH, et al., Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. EMBO J. 2012;31(11):2486-97
• All: 1 reference(s)