Actl6a^tm1.1Grc
Targeted Allele Detail

Summary

• Symbol: Actl6a^tm1.1Grc
• Name: actin-like 6A; targeted mutation 1.1, Gerald R Crabtree
• MGI ID: MGI:5427581
• Synonyms: BAF53a^fl, BAF53a flox
• Gene: Actl6a Location: Chr3:32762695-32781122 bp, + strand Genetic Position: Chr3, 15.83 cM
• Alliance: Actl6a^tm1.1Grc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192124
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin resistance cassette with a thymidine kinase (TK) promoter was inserted between both exon 5 and 6, and exons 3 and 4. Cre-mediated recombination removed the neo cassette and left exon 4 and 5 floxed. (J:192124)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Actl6a Mutation: 41 strains or lines available

References

• Original: J:192124 Krasteva V, et al., The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell function. Blood. 2012 Dec 6;120(24):4720-32
• All: 3 reference(s)