Fcor^tm1Jnak
Targeted Allele Detail

Summary

• Symbol: Fcor^tm1Jnak
• Name: Foxo1 corepressor; targeted mutation 1, Jun Nakae
• MGI ID: MGI:5427592
• Gene: Fcor Location: Chr8:3721188-3722362 bp, - strand Genetic Position: Chr8, 1.92 cM
• Alliance: Fcor^tm1Jnak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184684
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced wuth a lox71 site, lacZ gene polyadenylation site, FRT-flanked neo cassette, loxP site and polyadenlylation. (J:184684)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fcor Mutation: 1 strain or line available

References

• Original: J:184684 Nakae J, et al., Novel repressor regulates insulin sensitivity through interaction with Foxo1. EMBO J. 2012 May 16;31(10):2275-95
• All: 2 reference(s)