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Mecp2tm1.1Mitoh
Targeted Allele Detail
Summary
Symbol: Mecp2tm1.1Mitoh
Name: methyl CpG binding protein 2; targeted mutation 1.1, Masayuki Itoh
MGI ID: MGI:5427621
Synonyms: Xe2-
Gene: Mecp2  Location: ChrX:73070198-73129296 bp, - strand  Genetic Position: ChrX, 37.63 cM
Alliance: Mecp2tm1.1Mitoh page
Placentas of embryos carrying a maternal Mecp2tm1.1Mitoh allele exhibit increased apoptosis

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184364
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a modified exon 2 containing the untranslated region (2x) fused to a tetracycline transactivator (2x-tTA), a loxP site, an FRT-flanked neo cassette, a tetracycline responsive promoter (TRE) fused to the coding sequence of exon 2 (2y; TRE-2y), and a loxP site. Cre-mediated recombination removed the neo cassette and TRE-2y. (J:184364)
Generation of the Mecp2tm1.1Mitoh allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mecp2 Mutation:  41 strains or lines available
References
Original:  J:184364 Itoh M, et al., Methyl CpG-binding protein isoform MeCP2_e2 is dispensable for Rett syndrome phenotypes but essential for embryo viability and placenta development. J Biol Chem. 2012 Apr 20;287(17):13859-67
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory