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Drd1tm1.1(IL2RA/Venus)Koba
Targeted Allele Detail
Summary
Symbol: Drd1tm1.1(IL2RA/Venus)Koba
Name: dopamine receptor D1; targeted mutation 1.1, Kazuto Kobayashi
MGI ID: MGI:5427817
Synonyms: Drd1KI
Gene: Drd1  Location: Chr13:54205202-54209677 bp, - strand  Genetic Position: Chr13, 28.4 cM
Alliance: Drd1tm1.1(IL2RA/Venus)Koba page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184374
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA Venus reporter fused to human IL2RA with a polydaenylation sequence and a floxed neo cassette was inserted upstream of exon 2. Cre-mediated recombination removed the neo cassette. Treatment with a recombinant immunotoxin (variable anti-IL2RA regions fused to a bacterial exotoxin fragment) results in ablation of cells expressing this allele. (J:184374)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd1 Mutation:  70 strains or lines available
References
Original:  J:184374 Fukabori R, et al., Striatal direct pathway modulates response time in execution of visual discrimination. Eur J Neurosci. 2012 Mar;35(5):784-97
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory