Znrf3^tm1.1Fcon
Targeted Allele Detail

Summary

• Symbol: Znrf3^tm1.1Fcon
• Name: zinc and ring finger 3; targeted mutation 1.1, Feng Cong
• MGI ID: MGI:5427833
• Gene: Znrf3 Location: Chr11:5226329-5394847 bp, - strand Genetic Position: Chr11, 3.46 cM
• Alliance: Znrf3^tm1.1Fcon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184507
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 7. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 7. Cre-mediated recombination removed exon 7 and left the neo cassette intact. (J:184507)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Znrf3 Mutation: 37 strains or lines available

References

• Original: J:184507 Hao HX, et al., ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature. 2012 May 10;485(7397):195-200
• All: 1 reference(s)