Pik3c3tm1.1Flv
Targeted Allele Detail
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Symbol: |
Pik3c3tm1.1Flv |
Name: |
phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1.1, Richard A Flavell |
MGI ID: |
MGI:5427838 |
Synonyms: |
Pik3c3flox |
Gene: |
Pik3c3 Location: Chr18:30405800-30481179 bp, + strand Genetic Position: Chr18, 17.41 cM
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Alliance: |
Pik3c3tm1.1Flv page
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Germline Transmission: |
Earliest citation of germline transmission:
J:184753
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Parent Cell Line: |
JM8 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exon 4 floxed.
(J:184753)
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Generation of the Pik3c3tm1.1Flv allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pik3c3 Mutation: |
47 strains or lines available
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Original: |
J:184753 Willinger T, et al., Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8670-5 |
All: |
4 reference(s) |
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