Pik3c3^tm1.1Flv
Targeted Allele Detail

Summary

• Symbol: Pik3c3^tm1.1Flv
• Name: phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1.1, Richard A Flavell
• MGI ID: MGI:5427838
• Synonyms: Pik3c3^flox
• Gene: Pik3c3 Location: Chr18:30405800-30481179 bp, + strand Genetic Position: Chr18, 17.41 cM
• Alliance: Pik3c3^tm1.1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184753
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exon 4 floxed. (J:184753)

Generation of the Pik3c3^tm1.1Flv allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3c3 Mutation: 48 strains or lines available

References

• Original: J:184753 Willinger T, et al., Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8670-5
• All: 4 reference(s)