Astl^tm1Dean
Targeted Allele Detail

Summary

• Symbol: Astl^tm1Dean
• Name: astacin like metalloendopeptidase; targeted mutation 1, Jurrien Dean
• MGI ID: MGI:5427881
• Synonyms: Astl^Null
• Gene: Astl Location: Chr2:127180559-127199571 bp, + strand Genetic Position: Chr2, 61.93 cM, cytoband F
• Alliance: Astl^tm1Dean page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185161
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 2 and 3 of the gene, containing the transcriptional and translational start sites, were replaced by a neomycin resistance marker. (J:185161)

Generation of the Astl^tm1Dean allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Astl Mutation: 23 strains or lines available

References

• Original: J:185161 Burkart AD, et al., Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy. J Cell Biol. 2012 Apr 2;197(1):37-44
• All: 5 reference(s)