Pax2^tm1Gdr
Targeted Allele Detail

Summary

• Symbol: Pax2^tm1Gdr
• Name: paired box 2; targeted mutation 1, Gregory R Dressler
• MGI ID: MGI:5427893
• Synonyms: Pax2^Eneo
• Gene: Pax2 Location: Chr19:44744484-44826310 bp, + strand Genetic Position: Chr19, 38.09 cM
• Alliance: Pax2^tm1Gdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184878
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An EGFP and FRT-flanked neo cassette were inserted upstream of the coding sequence in exon 1. Western blot analysis confirms reduce protein expression in E18.5 and neonatal kidneys. (J:184878)

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax2 Mutation: 44 strains or lines available

References

• Original: J:184878 Soofi A, et al., Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys. Dev Biol. 2012 May 1;365(1):241-50
• All: 1 reference(s)