Frem1^tm2.1Ksek
Targeted Allele Detail

Summary

• Symbol: Frem1^tm2.1Ksek
• Name: Fras1 related extracellular matrix protein 1; targeted mutation 2.1, Kiyotoshi Sekiguchi
• MGI ID: MGI:5427907
• Synonyms: Qbrick^RGE
• Gene: Frem1 Location: Chr4:82816164-82970576 bp, - strand Genetic Position: Chr4, 39.4 cM
• Alliance: Frem1^tm2.1Ksek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185210
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Inserted expressed sequence) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neo cassette was inserted upstream of a modified exon 4 in which nucleotide substitution (T to A) results in the amino acid substitution of glutamic acid for aspartic acid at position 207 (D207E). Cre-mediated recombination removed the neo cassette. (J:185210)

Generation of the Frem1^tm2.1Ksek allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Frem1 Mutation: 117 strains or lines available

References

• Original: J:185210 Kiyozumi D, et al., Basement membrane assembly of the integrin alpha8beta1 ligand nephronectin requires Fraser syndrome-associated proteins. J Cell Biol. 2012 May 28;197(5):677-89
• All: 1 reference(s)