Gsk3a^tm1.1Tac
Targeted Allele Detail

Summary

• Symbol: Gsk3a^tm1.1Tac
• Name: glycogen synthase kinase 3 alpha; targeted mutation 1.1, Taconic
• MGI ID: MGI:5427913
• Synonyms: GSK-3alpha^flox
• Gene: Gsk3a Location: Chr7:24927683-24937276 bp, - strand Genetic Position: Chr7, 13.73 cM
• Alliance: Gsk3a^tm1.1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184975
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 4 a via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 2 - 4 floxed. (J:184975)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsk3a Mutation: 18 strains or lines available

References

• Original: J:184975 Hurtado DE, et al., Selectively Silencing GSK-3 Isoforms Reduces Plaques and Tangles in Mouse Models of Alzheimer's Disease. J Neurosci. 2012 May 23;32(21):7392-402
• All: 3 reference(s)