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Mir34atm1.1Kry
Targeted Allele Detail
Summary
Symbol: Mir34atm1.1Kry
Name: microRNA 34a; targeted mutation 1.1, Gerard Karsentry
MGI ID: MGI:5427918
Gene: Mir34a  Location: Chr4:150152911-150153012 bp, + strand  Genetic Position: Chr4, 80.85 cM
Alliance: Mir34atm1.1Kry page
Increased bone mass in Mir34atm1.1Kry/Mir34atm1.1Kry Mirc21tm1.1Kry/Mirc21tm1.1Kry Tg(Col1a1-cre)1Kry/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:185130
Parent Cell Line:  CSL3 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of the microRNA. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the microRNA. Flp-mediated recombination removed the neo cassette and left the microRNA floxed. (J:185130)
Generation of the Mir34atm1.1Kry allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mir34a Mutation:  9 strains or lines available
References
Original:  J:185130 Wei J, et al., miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J Cell Biol. 2012 May 14;197(4):509-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory