Mirc21^tm1.1Kry
Targeted Allele Detail

Summary

• Symbol: Mirc21^tm1.1Kry
• Name: microRNA cluster 21, including Mir34c through Mir34b; targeted mutation 1.1, Gerard Karsentry
• MGI ID: MGI:5427919
• Synonyms: miR-34bc^fl
• Gene: Mirc21 Location: Chr9:51014334-51014945 bp Genetic Position: Chr9, Syntenic

Increased bone mass in Mirc21^tm1.1Kry/Mirc21^tm1.1Kry Tg(Col1a1-cre)1Kry/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185130
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of the cluster and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the cluster. Flp-mediated recombination removed the neo cassette and left the cluster floxed. (J:185130)

Generation of the Mirc21^tm1.1Kry allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc21 Mutation: 5 strains or lines available

References

• Original: J:185130 Wei J, et al., miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J Cell Biol. 2012 May 14;197(4):509-21
• All: 1 reference(s)