Fcgr2b^tm1.2Jsv
Targeted Allele Detail

Summary

• Symbol: Fcgr2b^tm1.2Jsv
• Name: Fc receptor, IgG, low affinity IIb; targeted mutation 1.2, J Sjef Verbeek
• MGI ID: MGI:5427927
• Synonyms: Fcgr2b^tm1.2Sjv, FcgRIIBB6^-
• Gene: Fcgr2b Location: Chr1:170786186-170804116 bp, - strand Genetic Position: Chr1, 78.02 cM
• Alliance: Fcgr2b^tm1.2Jsv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179175
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed the neo cassette and exons 4 and 5. Flow cytometry confirmed the near absence of protein expression in B cells. (J:179175)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fcgr2b Mutation: 49 strains or lines available

References

• Original: J:179175 Boross P, et al., The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility. J Immunol. 2011 Aug 1;187(3):1304-13
• All: 10 reference(s)