Tmsb4x^tm1.1Chen
Targeted Allele Detail

Summary

• Symbol: Tmsb4x^tm1.1Chen
• Name: thymosin, beta 4, X chromosome; targeted mutation 1.1, Ju Chen
• MGI ID: MGI:5427989
• Synonyms: tbeta4^-
• Gene: Tmsb4x Location: ChrX:165990089-165992311 bp, - strand Genetic Position: ChrX, 78.28 cM
• Alliance: Tmsb4x^tm1.1Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185264
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated recombination of loxP sites resulted in the deletion of exon 2. Western blot analysis of heart tissue derived from homozygous mice confirmed absence of the expressed protein. (J:185264)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmsb4x Mutation: 12 strains or lines available

References

• Original: J:185264 Banerjee I, et al., Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res. 2012 Feb 3;110(3):456-64
• All: 3 reference(s)