Pcsk7^tm1Rob
Targeted Allele Detail

Summary

• Symbol: Pcsk7^tm1Rob
• Name: proprotein convertase subtilisin/kexin type 7; targeted mutation 1, Elizabeth Robertson
• MGI ID: MGI:5428017
• Gene: Pcsk7 Location: Chr9:45817795-45841024 bp, + strand Genetic Position: Chr9, 25.32 cM
• Alliance: Pcsk7^tm1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78623
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 3 through 7 were deleted, including sequences encoding the translational start site, the pro region, and the entirecatalytic domain of PC7. (J:78623, J:227651)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcsk7 Mutation: 30 strains or lines available

References

• Original: J:78623 Villeneuve P, et al., Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study. J Neurochem. 2002 Aug;82(4):783-93
• All: 6 reference(s)