Nefm^tm1Milg
Targeted Allele Detail

Summary

• Symbol: Nefm^tm1Milg
• Name: neurofilament, medium polypeptide; targeted mutation 1, Michael L Garcia
• MGI ID: MGI:5428135
• Synonyms: NF-M^BovineTail
• Gene: Nefm Location: Chr14:68356994-68362453 bp, - strand Genetic Position: Chr14, 35.46 cM
• Alliance: Nefm^tm1Milg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184861
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Nefm^tm1Milg expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  cattle	NEFM (281347)	Homology relationship from HCOP

• Exon 3 was replaced with the corresponding sequence and 3' UTR from bovine and a neo cassette. (J:184861)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nefm Mutation: 28 strains or lines available

References

• Original: J:184861 Barry DM, et al., Expansion of neurofilament medium C terminus increases axonal diameter independent of increases in conduction velocity or myelin thickness. J Neurosci. 2012 May 2;32(18):6209-19
• All: 1 reference(s)