Hprt1^{tm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Genoway
• MGI ID: MGI:5428335
• Synonyms: PLB1
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180977
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: A construct containing the Camk2a promoter, loxP site, human APP cDNA with the Sweden and London mutations (K670N, M671L and V717I), FRT site, IRES, loxP site, human MAPT cDNA with P301L and R406W mutations, FRT site and neo cassette was inserted into the locus. (J:180977)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:180977 Platt B, et al., Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1. PLoS One. 2011;6(11):e27068
• All: 2 reference(s)