Tg(Atoh7-cre)360Gla
Transgene Detail

Summary

• Symbol: Tg(Atoh7-cre)360Gla
• Name: transgene insertion 360, Tom Glaser
• MGI ID: MGI:5428439
• Synonyms: Math5>Cre
• Transgene: Tg(Atoh7-cre)360Gla Location: unknown
• Alliance: Tg(Atoh7-cre)360Gla page

Transgene origin

• Strain of Origin: (SJL x C57BL/6J)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Atoh7-cre)360Gla expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Atoh7 (MGI:1355553)

• Mutation details: A recA-mediated recombination protocol in E.coli replaced the open reading frame of Atoh7 with a cre recombinase cassette with a nuclear localization signal (nls) and a polyA signal in the Atoh7-containing BAC RP23-38P3. The purified, linearized BAC construct was injected itno fertilized (SJL x C57BL/6J)F2 oocytes. 9 founders were obtained. Lines 872 and 360 were established and crossed to Z/AP reporter mice to assess cre activity. Line 360 was utilized in subsequent experiments. (J:184871)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Atoh7 (mouse) Summary of all recombinase alleles driven by Atoh7. Alliance mouse Atoh7 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:184871 Brzezinski JA 4th, et al., Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle. Dev Biol. 2012 May 15;365(2):395-413
• All: 2 reference(s)