Tg(Prrx1-FUS/DDIT3)1Mete
Transgene Detail

Summary

• Symbol: Tg(Prrx1-FUS/DDIT3)1Mete
• Name: transgene insertion 1, Melissa Terry
• MGI ID: MGI:5428676
• Synonyms: Prx1-TLS:CHOP, pTC, Tg(Prrx1-TLS/CHOP)1Mete
• Transgene: Tg(Prrx1-FUS/DDIT3)1Mete Location: unknown
• Alliance: Tg(Prrx1-FUS/DDIT3)1Mete page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prrx1-FUS/DDIT3)1Mete expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DDIT3 (1649)

  Ddit3

  (MGI:109247)

  human

  FUS (2521)

  Fus	(MGI:1353633)

• Mutation details: The mouse promoter drives mesenchyme-specific expression of a human cDNA encoding the fusion of FUS and DDIT3 (TLS:CHOP; type II). The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:184491)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:184491 Charytonowicz E, et al., PPARgamma agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma. J Clin Invest. 2012 Mar 1;122(3):886-98
• All: 1 reference(s)