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Fcgr4tm1.1Rav
Targeted Allele Detail
Summary
Symbol: Fcgr4tm1.1Rav
Name: Fc receptor, IgG, low affinity IV; targeted mutation 1.1, Jeffrey V Ravetch
MGI ID: MGI:5428684
Gene: Fcgr4  Location: Chr1:170846495-170857330 bp, + strand  Genetic Position: Chr1, 78.53 cM
Alliance: Fcgr4tm1.1Rav page
Decreased susceptibility to induced arthritis in Fcgr4tm1.1Rav/Fcgr4tm1.1Rav mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167375
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and loxP sites were inserted downstream of exon 3. Cre-mediated recombination removed exons 1 through 3. Immunohistochemistry confirmed the absence of protein expression in splenic macrophage. (J:167375)
Generation of the Fcgr4tm1Rav and Fcgr4tm1.1Rav alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fcgr4 Mutation:  26 strains or lines available
References
Original:  J:167375 Nimmerjahn F, et al., FcgammaRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19396-401
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory