Fcgr4tm1.1Rav
Targeted Allele Detail
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Symbol: |
Fcgr4tm1.1Rav |
Name: |
Fc receptor, IgG, low affinity IV; targeted mutation 1.1, Jeffrey V Ravetch |
MGI ID: |
MGI:5428684 |
Gene: |
Fcgr4 Location: Chr1:170846495-170857330 bp, + strand Genetic Position: Chr1, 78.53 cM
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Alliance: |
Fcgr4tm1.1Rav page
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Decreased susceptibility to induced arthritis in Fcgr4tm1.1Rav/Fcgr4tm1.1Rav mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:167375
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 1 and loxP sites were inserted downstream of exon 3. Cre-mediated recombination removed exons 1 through 3. Immunohistochemistry confirmed the absence of protein expression in splenic macrophage.
(J:167375)
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Generation of the Fcgr4tm1Rav and Fcgr4tm1.1Rav alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fcgr4 Mutation: |
26 strains or lines available
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Original: |
J:167375 Nimmerjahn F, et al., FcgammaRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19396-401 |
All: |
15 reference(s) |
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