Hprt1^{tm1(Nphs1-CMIP)Dsah}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(Nphs1-CMIP)Dsah}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Djillali Sahali
• MGI ID: MGI:5428689
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(Nphs1-CMIP)Dsah} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185411
• Parent Cell Line: BPES (ES Cell)
• Strain of Origin: (129-Hprt1^b-m3 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm1(Nphs1-CMIP)Dsah} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CMIP (80790)

  Cmip	(MGI:1921690)

• Mutation details: A transgene containing the mouse promoter driving podocyte-specifc expression of the human cDNA with a human HPRT sequence for selection was targeted to the locus. (J:185411)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:185411 Zhang SY, et al., c-mip impairs podocyte proximal signaling and induces heavy proteinuria. Sci Signal. 2010;3(122):ra39
• All: 1 reference(s)