Arap3^tm2.1Sve
Targeted Allele Detail

Summary

• Symbol: Arap3^tm2.1Sve
• Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3; targeted mutation 2.1, Sonja Vermeren
• MGI ID: MGI:5428755
• Synonyms: Aap3^R302,3A
• Gene: Arap3 Location: Chr18:38105681-38132022 bp, - strand Genetic Position: Chr18, 19.85 cM
• Alliance: Arap3^tm2.1Sve page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185401
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A self-excising neo cassette was inserted in intron 3 and an R302A and R303A point mutations were introduced in exon 5 via homologous recombination. (J:185401)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arap3 Mutation: 61 strains or lines available

References

• Original: J:185401 Gambardella L, et al., PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis. Sci Signal. 2010;3(145):ra76
• All: 3 reference(s)