Lrrn4^tm1Ami
Targeted Allele Detail

Summary

• Symbol: Lrrn4^tm1Ami
• Name: leucine rich repeat neuronal 4; targeted mutation 1, Atsushi Miyajima
• MGI ID: MGI:5428888
• Gene: Lrrn4 Location: Chr2:132710225-132722811 bp, - strand Genetic Position: Chr2, 64.78 cM
• Alliance: Lrrn4^tm1Ami page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185491
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 2.5-kb fragment containing the exon with initiation codon was replaced with the beta-galactosidase gene via homologous recombination. Flow cytometric analysis on homozygous embryos confirmed that the encoded protein was not detectable. (J:185491)

Expression

In Mice Carrying this Mutation:

72 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrrn4 Mutation: 36 strains or lines available

References

• Original: J:185491 Bando T, et al., Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory. Mol Cell Biol. 2005 May;25(10):4166-75
• All: 3 reference(s)