Sox17^tm3.1Heli
Targeted Allele Detail

Summary

• Symbol: Sox17^tm3.1Heli
• Name: SRY (sex determining region Y)-box 17; targeted mutation 3.1, Heiko Lickert
• MGI ID: MGI:5428890
• Synonyms: Sox17^SCF
• Gene: Sox17 Location: Chr1:4561154-4567577 bp, - strand Genetic Position: Chr1, 1.65 cM
• Alliance: Sox17^tm3.1Heli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185482
• Parent Cell Line: IDG3.2 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Mutation details: The translational stop codon in exon 5 was replaced with an in-frame open reading frame of mCherry followed by a floxed PGK-neo cassette. Cre mediated recombination removed the neo cassette. Expression and localization of the fusion protein recapitulates endogenous gene expression and localization. (J:185482)

Generation of the Sox17^tm3.1Heli allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox17 Mutation: 29 strains or lines available

References

• Original: J:185482 Burtscher I, et al., The Sox17-mCherry fusion mouse line allows visualization of endoderm and vascular endothelial development. Genesis. 2012 Jun;50(6):496-505
• All: 4 reference(s)