Bid^tm1.1Atgr
Targeted Allele Detail

Summary

• Symbol: Bid^tm1.1Atgr
• Name: BH3 interacting domain death agonist; targeted mutation 1.1, Atan Gross
• MGI ID: MGI:5428930
• Synonyms: BID^AA
• Gene: Bid Location: Chr6:120870080-120894074 bp, - strand Genetic Position: Chr6, 57.02 cM
• Alliance: Bid^tm1.1Atgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185449
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Serine to Alanine substitutions were engineered in codon 61 of exon 2 and in codon 78 of exon3. A floxed neomycin selection cassette was inserted in intron 2. The selection cassette was subsequently removed by crossing to cre deleter mice. (J:185449)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bid Mutation: 44 strains or lines available

References

• Original: J:185449 Maryanovich M, et al., The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells. Nat Cell Biol. 2012 May;14(5):535-41
• All: 2 reference(s)