Aim2^tm1.1Vmd
Targeted Allele Detail

Summary

• Symbol: Aim2^tm1.1Vmd
• Name: absent in melanoma 2; targeted mutation 1.1, Vishva M Dixit
• MGI ID: MGI:5428935
• Synonyms: Aim2^-
• Gene: Aim2 Location: Chr1:173178445-173293606 bp, + strand Genetic Position: Chr1, 80.33 cM
• Alliance: Aim2^tm1.1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160545
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 5 and a neo cassette and loxP site were inserted downstream of exon 5. Cre mediated recombination deleted exon 5 and the neo cassette. Western blot analysis confirmed the absence of gene expression in bone marrow derived macrophages from homozygous mice. (J:160545)

Generation of the Aim2^tm1.1Vmd allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aim2 Mutation: 35 strains or lines available

References

• Original: J:160545 Jones JW, et al., Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9771-6
• All: 49 reference(s)