Ksr2^tm2.1Lex
Targeted Allele Detail

Summary

• Symbol: Ksr2^tm2.1Lex
• Name: kinase suppressor of ras 2; targeted mutation 2.1 Lexicon Genetics
• MGI ID: MGI:5429066
• Synonyms: Ksr2c^-
• Gene: Ksr2 Location: Chr5:117552067-117906061 bp, + strand Genetic Position: Chr5, 56.88 cM
• Alliance: Ksr2^tm2.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185493
• Parent Cell Line: Lex-2 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 13 was deleted by Protaime-cre mediated recombination of loxP sites that flanked this exon. The encoded protein is absent in brain extracts derived from homozygous mice. (J:185493)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ksr2 Mutation: 42 strains or lines available

References

• Original: J:185493 Revelli JP, et al., Profound obesity secondary to hyperphagia in mice lacking kinase suppressor of ras 2. Obesity (Silver Spring). 2011 May;19(5):1010-8
• All: 1 reference(s)