Rag1^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Rag1^m2Btlr
• Name: recombination activating 1; mutation 2, Bruce Beutler
• MGI ID: MGI:5429068
• Gene: Rag1 Location: Chr2:101468627-101479846 bp, - strand Genetic Position: Chr2, 53.88 cM
• Alliance: Rag1^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU-mutagenesis induced T to A mutation that results in the amino acid substitution of a STOP codon for tyrosine at position 369 (Y369X). (J:185495)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rag1 Mutation: 123 strains or lines available

References

• Original: J:185495 Arnold CN, et al., A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12286-93
• All: 1 reference(s)