Cdk7^{Gt(D032B11)1.1Wrst}
Gene trapped Allele Detail

Summary

• Symbol: Cdk7^{Gt(D032B11)1.1Wrst}
• Name: cyclin dependent kinase 7; gene trap D032B11, 1.1, German Gene Trap Consortium
• MGI ID: MGI:5429213
• Synonyms: Cdk7^lox
• Gene: Cdk7 Location: Chr13:100839139-100867447 bp, - strand Genetic Position: Chr13, 53.23 cM
• Alliance: Cdk7^{Gt(D032B11)1.1Wrst} page

Mutation origin

• Mutant Cell Line: D032B11
• Germline Transmission: Earliest citation of germline transmission: J:183925
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: rFlpROSAbetageo
• Mutation details: Flp mediated recombination inverted the gene trap vector in intron 2 allowing expression of the gene. The gene trap vector has only single FRT and F3 sites. (J:183925)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdk7 Mutation: 138 strains or lines available

References

• Original: J:183925 Ganuza M, et al., Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J. 2012 May 30;31(11):2498-510
• All: 2 reference(s)