Tg(HLA-DR2)#Lfug
Transgene Detail

Summary

• Symbol: Tg(HLA-DR2)#Lfug
• Name: transgene insertion, Lars Fugger
• MGI ID: MGI:5429698
• Synonyms: DR2, Dr2b tg, HLA-DR2
• Transgene: Tg(HLA-DR2)#Lfug Location: unknown
• Alliance: Tg(HLA-DR2)#Lfug page

Transgene origin

• Strain of Origin: (DBA/2 x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(HLA-DR2)#Lfug expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HLA-DRA (3122)

  H2-Ea

  (MGI:95900)

• Mutation details: The murine MHC class II gene Ea promoter drives expression of the human HLA-DRA*0101 and HLA-DRB1*1501 DNAs. The HLA-DRA*0101 and HLA-DRB1*1501 are MS susceptibility genes found in individuals of European descent. (J:134764)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:134764 Madsen LS, et al., A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat Genet. 1999 Nov;23(3):343-7
• All: 7 reference(s)