Tg(TCROb.1A12)#Lfug
Transgene Detail

Summary

• Symbol: Tg(TCROb.1A12)#Lfug
• Name: transgene insertion, Lars Fugger
• MGI ID: MGI:5429700
• Synonyms: TCR
• Transgene: Tg(TCROb.1A12)#Lfug Location: unknown
• Alliance: Tg(TCROb.1A12)#Lfug page

Transgene origin

• Strain of Origin: (DBA/2 x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TCROb.1A12)#Lfug expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TRA (6955)

  Trac	(MGI:4439838)

  human

  TRB (6957)

  Trbc1	(MGI:4439726)
  Trbc2	(MGI:4835227)

• Mutation details: V-(D)-J rearrangements of TCRA and TCRB from clone Ob.1A12 were inserted in cassettes containing mouse Tcra and Tcrb constant and promoter/enhancer sequences. The Ob.1A12 clone was derived from an MS patient. (J:134764)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:134764 Madsen LS, et al., A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat Genet. 1999 Nov;23(3):343-7
• All: 6 reference(s)