b2b576Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b576Clo
• Name: Mutant line 576; Bench to Bassinet Program (B2B/CVDC), mutation 576 Cecilia Lo
• MGI ID: MGI:5430052
• Synonyms: Rugby
• Gene: b2b576Clo Location: unknown
• Alliance: b2b576Clo page

Mutant 576-006-NA displays malpositioning of the great arteries, shown to be overriding aorta by EFIC histopathology

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b576Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Cardiac defects: Malalignment of the great arteries - double outlet right ventricle (DORV)/overriding Aorta (Ao).

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
1432	Overriding aortic valve
0600	Double outlet right ventricle

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 3 reference(s)