Gja1^tm4Gfi
Targeted Allele Detail

Summary

• Symbol: Gja1^tm4Gfi
• Name: gap junction protein, alpha 1; targeted mutation 4, Glen I Fishman
• MGI ID: MGI:5430315
• Synonyms: Cx43^S3E
• Gene: Gja1 Location: Chr10:56253297-56266519 bp, + strand Genetic Position: Chr10, 28.64 cM
• Alliance: Gja1^tm4Gfi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185692
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Codons for amino acid residues 325, 328, and 330 were modified to replace the encoded serine with glutamic acid (S325E, S328E, S330E). (J:185692)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gja1 Mutation: 60 strains or lines available

References

• Original: J:185692 Remo BF, et al., Phosphatase-resistant gap junctions inhibit pathological remodeling and prevent arrhythmias. Circ Res. 2011 Jun 10;108(12):1459-66
• All: 2 reference(s)