Tcf7l2^tm2.1Cle
Targeted Allele Detail

Summary

• Symbol: Tcf7l2^tm2.1Cle
• Name: transcription factor 7 like 2, T cell specific, HMG box; targeted mutation 2.1, Hans Clever
• MGI ID: MGI:5430317
• Synonyms: Tcf4^LoxP
• Gene: Tcf7l2 Location: Chr19:55730252-55922086 bp, + strand Genetic Position: Chr19, 51.59 cM
• Alliance: Tcf7l2^tm2.1Cle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185753
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 11. An additional loxP site was inserted downstream of exon 11. Flp-mediated recombination removed the neo cassette and left exon 11 floxed. (J:185753)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf7l2 Mutation: 58 strains or lines available

References

• Original: J:185753 van Es JH, et al., A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. Mol Cell Biol. 2012 May;32(10):1918-27
• All: 6 reference(s)