Tg(Dyrk1a)189N3Yah
Transgene Detail

Summary

• Symbol: Tg(Dyrk1a)189N3Yah
• Name: transgene insertion 189N3, Yann Herault
• MGI ID: MGI:5430362
• Synonyms: mBACtgDyrk1a, TgDyrk1A, Tg(Dyrk1a)#Jmd
• Transgene: Tg(Dyrk1a)189N3Yah Location: unknown
• Alliance: Tg(Dyrk1a)189N3Yah page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:182294
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Dyrk1a)189N3Yah expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Dyrk1a (MGI:1330299)

• Mutation details: This transgene consists of a 152 kb bacterial artificial chromosome clone, 189N3, containing the whole mouse Dyrk1a gene with a 6 kb flanking fragment on the 5' side and a 19 kb flanking fragment on the 3' side and retrofitted to containa a PGKneo cassette (189N3 BAC clone from Research Genetics). The clone contains only the Dyrk1a gene and this transgene contains one extra copy of Dyrk1a. (J:182294)

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:182294 Guedj F, et al., DYRK1A: A master regulatory protein controlling brain growth. Neurobiol Dis. 2012 Apr;46(1):190-203
• All: 14 reference(s)