Tg(Pax6-HRAS*G12V)2044Ove
Transgene Detail

Summary

• Symbol: Tg(Pax6-HRAS*G12V)2044Ove
• Name: transgene insertion 2044, Paul A Overbeek
• MGI ID: MGI:5430364
• Synonyms: OVE2044
• Transgene: Tg(Pax6-HRAS*G12V)2044Ove Location: unknown
• Alliance: Tg(Pax6-HRAS*G12V)2044Ove page

Altered lens and corneal development inTg(Pax6-HRAS*G12V)2044Ove/0 mice

Show the 4 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pax6-HRAS*G12V)2044Ove expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HRAS (3265)

  Hras	(MGI:96224)

• Mutation details: A Pax6 promoter enhancer fragment drives expression a human HRAS genomic clone containing a G12V mutation. (J:158529)

Schematic diagram of the Tg(Pax6-HRAS*G12V)2044Ove transgene

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:158529 Burgess D, et al., Activated Ras alters lens and corneal development through induction of distinct downstream targets. BMC Dev Biol. 2010;10:13
• All: 2 reference(s)