Gt(ROSA)26Sor^{tm1(NOTCH1/GFP)Xhsu}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(NOTCH1/GFP)Xhsu}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Xiao-Hong Sun
• MGI ID: MGI:5430379
• Synonyms: ROSA26-stop-N1C
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(NOTCH1/GFP)Xhsu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185287
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(NOTCH1/GFP)Xhsu} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NOTCH1 (4851)

  Notch1

  (MGI:97363)

• Mutation details: A floxed stop cassette, the SalI-SalI fragment containing the human NOTCH1 intracellular domain (N1C) and GFP sequence were inserted into the locus. (J:185287)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 991 strains or lines available

References

• Original: J:185287 Wang HC, et al., Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic mice. PLoS One. 2012;7(2):e32944
• All: 2 reference(s)