Ugdh^tm1.1Xzh
Targeted Allele Detail

Summary

• Symbol: Ugdh^tm1.1Xzh
• Name: UDP-glucose dehydrogenase; targeted mutation 1.1, Xin Zhang
• MGI ID: MGI:5430380
• Gene: Ugdh Location: Chr5:65570550-65593185 bp, - strand Genetic Position: Chr5, 33.67 cM
• Alliance: Ugdh^tm1.1Xzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185652
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 6 and a loxP site was inserted downstream of exon 6 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:185652)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ugdh Mutation: 34 strains or lines available

References

• Original: J:185652 Qu X, et al., Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development. Development. 2012 Aug;139(15):2730-9
• All: 3 reference(s)