Tg(Lck-Id1)28Xhsu
Transgene Detail

Summary

• Symbol: Tg(Lck-Id1)28Xhsu
• Name: transgene insertion 28, Xiao-Hong Sun
• MGI ID: MGI:5430381
• Synonyms: Id1-28
• Transgene: Tg(Lck-Id1)28Xhsu Location: unknown
• Alliance: Tg(Lck-Id1)28Xhsu page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-Id1)28Xhsu expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Id1 (MGI:96396)

• Mutation details: The T-cell-specific proximal promoterand human growth hormone gene intron and polyadenylation signal drives expression of the mouse cDNA. Lines 28 and 29 were generated. Line 29 contains leakier block of T cell differentiation than line 28. (J:58607)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(Lck-Id1)28Xhsu/0	Not Specified

Phenotypes:

Affected Systems	tg1
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endocrine/exocrine glands	√
increased T cell derived lymphoma incidence	√
hematopoietic system	√
increased T cell derived lymphoma incidence	√
immune system	√
increased T cell derived lymphoma incidence	√
mortality/aging	√
premature death	√
neoplasm	√
increased T cell derived lymphoma incidence	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:58607 Kim D, et al., Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice. Mol Cell Biol. 1999 Dec;19(12):8240-53
• All: 5 reference(s)