Tcf7l1^tm1.1Bjme
Targeted Allele Detail

Summary

• Symbol: Tcf7l1^tm1.1Bjme
• Name: transcription factor 7 like 1 (T cell specific, HMG box); targeted mutation 1.1, Bradley J Merrill
• MGI ID: MGI:5430599
• Synonyms: Tcf3^deltaN
• Gene: Tcf7l1 Location: Chr6:72603354-72766028 bp, - strand Genetic Position: Chr6, 32.27 cM
• Alliance: Tcf7l1^tm1.1Bjme page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185554
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The residues required for binding to beta-catenin were deleted and a floxed neo cassette was inserted via homologous recombination. Cre mediated recombination removed the neo cassette. This allele expresses a stable mutant mRNA and protein. (J:174449)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf7l1 Mutation: 84 strains or lines available

References

• Original: J:174449 Yi F, et al., Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol. 2011;13(7):762-70
• All: 5 reference(s)