Ifit2^tm1.1Ebsb
Targeted Allele Detail

Summary

• Symbol: Ifit2^tm1.1Ebsb
• Name: interferon-induced protein with tetratricopeptide repeats 2; targeted mutation 1.1, Erwin Bohn
• MGI ID: MGI:5430603
• Gene: Ifit2 Location: Chr19:34528094-34553819 bp, + strand Genetic Position: Chr19, 29.73 cM
• Alliance: Ifit2^tm1.1Ebsb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199862
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced part of exon 3. Cre-mediated recombination removed the neomycin resistance cassette. (J:199862)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifit2 Mutation: 26 strains or lines available

References

• Original: J:199862 Siegfried A, et al., IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-alpha secretion and LPS-induced endotoxin shock. J Immunol. 2013 Oct 1;191(7):3913-21
• All: 4 reference(s)