Itgb1^tm13.1Ref
Targeted Allele Detail

Summary

• Symbol: Itgb1^tm13.1Ref
• Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 13.1, Reinhard Fassler
• MGI ID: MGI:5430791
• Synonyms: beta1 TT/AA
• Gene: Itgb1 Location: Chr8:129412135-129459681 bp, + strand Genetic Position: Chr8, 76.09 cM, cytoband E2
• Alliance: Itgb1^tm13.1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185558
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neo cassette was inserted downstream of a modified exon 16 in which nucleotide substitutions result in the amino acid substitutions of alanine for threonine at positions 788 and 789 (T788A and T789A). This amino acid substitutions prevent Kindlin (Fermt) binding. Cre-mediated recombination removed the neo cassette. (J:177979, J:185558)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb1 Mutation: 60 strains or lines available

References

• Original: J:185558 Bottcher RT, et al., Sorting nexin 17 prevents lysosomal degradation of beta1 integrins by binding to the beta1-integrin tail. Nat Cell Biol. 2012 Jun;14(6):584-92
• All: 3 reference(s)