Rab38^em1Rkuhn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rab38^em1Rkuhn
• Name: RAB38, member RAS oncogene family; endonuclease-mediated mutation 1, Ralf Kuhn
• MGI ID: MGI:5430811
• Synonyms: Rab38^IDG-Cht
• Gene: Rab38 Location: Chr7:88079481-88140780 bp, + strand Genetic Position: Chr7, 49.19 cM
• Alliance: Rab38^em1Rkuhn page

Mutation origin

• Strain of Origin: (FVB/NCrl x C57BL/6NCrl)F1

Mutation description

• Allele Type: Endonuclease-mediated
• Mutation: Nucleotide substitutions
• Mutation details: Zinc finger endonuclease mediated homologous recombination introduced nucleotide substitutions (GGT to GTA) that result in the amino acid substitution of glycine with valine at position 19 (G19V). This mutation replicated the amino acid substitution observed in Rab38^cht. (J:185512)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab38 Mutation: 15 strains or lines available

References

• Original: J:185512 Meyer M, et al., Modeling disease mutations by gene targeting in one-cell mouse embryos. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9354-9
• All: 1 reference(s)