Pip5k1a^tm1.1Tba
Targeted Allele Detail

Summary

• Symbol: Pip5k1a^tm1.1Tba
• Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha; targeted mutation 1.1, Tadashi Baba
• MGI ID: MGI:5430936
• Gene: Pip5k1a Location: Chr3:94965841-95014241 bp, - strand Genetic Position: Chr3, 40.74 cM
• Alliance: Pip5k1a^tm1.1Tba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185835
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:185835)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pip5k1a Mutation: 67 strains or lines available

References

• Original: J:185835 Hasegawa H, et al., Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis. Biol Reprod. 2012;86(5):136, 1-12
• All: 1 reference(s)