Spart^tm1.1Xen
Targeted Allele Detail

Summary

• Symbol: Spart^tm1.1Xen
• Name: spartin; targeted mutation 1.1, Taconic Biosciences
• MGI ID: MGI:5430946
• Gene: Spart Location: Chr3:55019529-55044743 bp, + strand Genetic Position: Chr3, 26.53 cM
• Alliance: Spart^tm1.1Xen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185987
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 2 and all of exons 3 through 5 were replaced with a luciferase reporter and a floxed neo cassette. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in the brain, spinal cord and testis. (J:185987)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spart Mutation: 33 strains or lines available

References

• Original: J:185987 Renvoise B, et al., Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling. Hum Mol Genet. 2012 Aug 15;21(16):3604-18
• All: 1 reference(s)